Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents

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Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents.

A new series of fourteen dicationic flexible triaryl bis-guanidines 3a,b, bis-N-substituted guanidines 7a,b and 8a,b as well as bis-imidamides 9-12a,b having a 1,3- or 1,4-diphenoxybenzene scaffold backbone were synthesized. The in vitro activity of the novel dications as antiprotozoal agents against Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum (P.f.) was assessed. Interest...

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ژورنال

عنوان ژورنال: European Journal of Medicinal Chemistry

سال: 2008

ISSN: 0223-5234

DOI: 10.1016/j.ejmech.2008.02.008